If you see a headline that says ‘genetic variant linked to higher body mass index’, what that usually means is that, on average, people that have one version of a genetic variant (an ‘A’ letter in their DNA code, for example) have a higher BMI than those with the other version (a ‘T’ letter in … More Finding genetic effects on phenotypic variability
Whether resemblance between relatives is due to genes (nature) or environment (including nurture) has generated much controversy, especially for traits like education and intelligence. The modern scientific effort to disentangle nature and nurture can be traced, in large part, back to Charles Darwin’s cousin, Francis Galton. Prompted by Darwin’s theory of evolution by natural selection, … More Relatedness disequilibrium regression explained
I am writing this post to answer some of the reactions I got to my recent article on ‘Estimating heritability without environmental bias‘, in which I develop a novel method, RDR, to estimate heritability, and apply it to 14 human traits. RDR uses IBD segments to infer heritability. RDR therefore handles rare variants similarly to … More RDR and rare variants
My talk at Probabilistic Modeling in Genomics at Cold Spring Harbor (2015) on using an efficient heteroskedastic linear mixed model to find loci involved in interactions in genome-wide association studies.