I am writing this post to answer some of the reactions I got to my recent article on ‘Estimating heritability without environmental bias‘, in which I develop a novel method, RDR, to estimate heritability, and apply it to 14 human traits. RDR uses IBD segments to infer heritability. RDR therefore handles rare variants similarly to … More RDR and rare variants
In the first part of this series of blog posts, I gave my definition of heritability. I defined heritability as the fraction of trait variability explained by direct genetic effects alone. Direct genetic effects are the effect of genetic variants in a body on that body. They are distinguished from indirect genetic effects, which are … More Heritability estimation: the central problem (ii)
This post aims to define what heritability is. We define and estimate heritability so that we can measure the relative importance of genetic inheritance versus environment in explaining differences between individuals in a population. The relative importance of genetic inheritance (nature) versus environment (including nurture) for human traits has generated much controversy over the years. … More Heritability Estimation: what is heritability? (I)
My talk at Probabilistic Modeling in Genomics at Cold Spring Harbor (2015) on using an efficient heteroskedastic linear mixed model to find loci involved in interactions in genome-wide association studies.