I decided to write this blog post to accompany my appearance on the Insight Podcast, where I talked about heritability, how much of it is ‘missing’, and what the the recent preprint from Peter Visscher’s group has shown. Heritability is the fraction of trait variation in a population due to genetic inheritance (see here). As I … More Missing heritability revisited
If you see a headline that says ‘genetic variant linked to higher body mass index’, what that usually means is that, on average, people that have one version of a genetic variant (an ‘A’ letter in their DNA code, for example) have a higher BMI than those with the other version (a ‘T’ letter in … More Finding genetic effects on phenotypic variability
Whether resemblance between relatives is due to genes (nature) or environment (including nurture) has generated much controversy, especially for traits like education and intelligence. The modern scientific effort to disentangle nature and nurture can be traced, in large part, back to Charles Darwin’s cousin, Francis Galton. Prompted by Darwin’s theory of evolution by natural selection, … More Relatedness disequilibrium regression explained
My talk at Probabilistic Modeling in Genomics at Cold Spring Harbor (2015) on using an efficient heteroskedastic linear mixed model to find loci involved in interactions in genome-wide association studies.