Interactions between genetic variants and environmental variables give rise to situations where the effect of a genetic variant depends upon the state of some environment variables or, equivalently, the effect of an environmental variable depends upon some genetic variables. R.A. Fisher was the first person to define statistical epistasis (Part II), and he was the … More Interactions in genetics III: gene-by-environment interactions

This is the second part of a series of posts on interactions in genetics. In this post, we look at interactions between genetic variants, where those interactions can either be within loci (dominance effects) or between loci (epistasis). In Part I, we saw that an interaction was defined by a departure from additivity, where the … More Interactions in Genetics II: Epistasis and Dominance

This is the first in a series of blog posts on interactions in genetics. I will cover the general statistical concept of an interaction for, then look at gene-gene (epistasis) and gene-by-environment interactions. The common-sense notion of an interaction between two things implies that the two exert some causal influence on each other, resulting in … More Interactions in Genetics I: what is an interaction?